USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: EF1A1_HUMAN USC-OGP 2-DE database:  EF1A1_HUMAN EF1A1_HUMAN General information about the entry View entry in simple text format Entry name EF1A1_HUMAN Primary accession number P68104 Secondary accession number(s) P04720 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Elongation factor 1-alpha 1; Short=EF-1-alpha-1; AltName: Full=Elongation factor Tu; Short=EF-Tu; AltName: Full=Eukaryotic elongation factor 1 A-1; Short=eEF1A-1; AltName: Full=Leukocyte receptor cluster member 7;. Gene name Name=EEF1A1 Synonyms=EEF1A, EF1A, LENG7 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0922: pI=8.82; Mw=46903 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1162: pI=6.22; Mw=49435 SPOT OGP-1167: pI=6.89; Mw=47770 Cross-references UniProtKB/Swiss-Prot P68104; EF1A1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name EF1A1_HUMAN Primary accession number P68104 Secondary accession number(s) P04719 P04720 Q6IQ15 Sequence was last modified on  August 13, 1987 (version 1) Annotations were last modified on  March 15, 2017 (version 158) Name and origin of the protein Description RecName: Full=Elongation factor 1-alpha 1; Short=EF-1-alpha-1; AltName: Full=Elongation factor Tu; Short=EF-Tu; AltName: Full=Eukaryotic elongation factor 1 A-1; Short=eEF1A-1; AltName: Full=Leukocyte receptor cluster member 7; Gene name Name=EEF1A1 Synonyms=EEF1A, EF1A, LENG7 Encoded on Name=EEF1A1; Synonyms=EEF1A, EF1A, LENG7 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Elongation factor; GTP-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X03558; CAA27245.1; -; mRNA EMBL J04617; AAA52343.1; -; Genomic_DNA EMBL X16869; CAA34756.1; -; mRNA EMBL AY043301; AAK95378.1; -; mRNA EMBL BC008587; AAH08587.1; -; mRNA EMBL BC009733; AAH09733.1; -; mRNA EMBL BC009875; AAH09875.1; -; mRNA EMBL BC010735; AAH10735.1; -; mRNA EMBL BC012891; AAH12891.1; -; mRNA EMBL BC014224; AAH14224.1; -; mRNA EMBL BC018150; AAH18150.1; -; mRNA EMBL BC018641; AAH18641.1; -; mRNA EMBL BC021686; AAH21686.1; -; mRNA EMBL BC028674; AAH28674.1; -; mRNA EMBL BC038339; AAH38339.1; -; mRNA EMBL BC057391; AAH57391.1; -; mRNA EMBL BC066893; AAH66893.1; -; mRNA EMBL BC071619; AAH71619.1; -; mRNA EMBL BC072385; AAH72385.1; -; mRNA EMBL BC082268; AAH82268.1; -; mRNA EMBL X03689; CAA27325.1; -; mRNA EMBL M29548; AAA52367.1; ALT_INIT; mRNA CCDS CCDS4980.1; -. [P68104-1]; . PIR B24977; EFHU1; . RefSeq NP_001393.1; NM_001402.5. [P68104-1]; . RefSeq XP_011533816.1; XM_011535514.2. [P68104-1]; . UniGene Hs.535192; -; . UniGene Hs.586423; -; . UniGene Hs.745122; -; . PDB 1SYW; Model; -; A=2-443 PDB 3C5J; X-ray; 1.80 A; C=343-355 PDBsum 1SYW; -; . PDBsum 3C5J; -; . ProteinModelPortal P68104; -; . SMR P68104; -; . BioGrid 108237; 389; . DIP DIP-31277N; -; . IntAct P68104; 182; . MINT MINT-1180846; -; . STRING 9606.ENSP00000330054; -; . BindingDB P68104; -; . ChEMBL CHEMBL1795120; -; . DrugBank DB04315; Guanosine-5'-Diphosphate; . iPTMnet P68104; -; . PhosphoSitePlus P68104; -; . SwissPalm P68104; -; . BioMuta EEF1A1; -; . DMDM 55584035; -; . OGP P68104; -; . SWISS-2DPAGE P68104; -; . UCD-2DPAGE P68104; -; . EPD P68104; -; . PaxDb P68104; -; . PeptideAtlas P68104; -; . PRIDE P68104; -; . DNASU 1915; -; . Ensembl ENST00000309268; ENSP00000339053; ENSG00000156508. [P68104-1]; . Ensembl ENST00000316292; ENSP00000339063; ENSG00000156508. [P68104-1]; . Ensembl ENST00000331523; ENSP00000330054; ENSG00000156508. [P68104-1]; . GeneID 1915; -; . KEGG hsa:1915; -; . CTD 1915; -; . DisGeNET 1915; -; . GeneCards EEF1A1; -; . H-InvDB HIX0020005; -; . H-InvDB HIX0032108; -; . H-InvDB HIX0033669; -; . H-InvDB HIX0169110; -; . HGNC HGNC:3189; EEF1A1; . HPA HPA051759; -; . HPA HPA053862; -; . HPA HPA056990; -; . MIM 130590; gene; . neXtProt NX_P68104; -; . OpenTargets ENSG00000156508; -; . PharmGKB PA27625; -; . eggNOG KOG0052; Eukaryota; . eggNOG COG5256; LUCA; . GeneTree ENSGT00670000097815; -; . HOGENOM HOG000229291; -; . HOVERGEN HBG000179; -; . InParanoid P68104; -; . KO K03231; -; . OMA FEQISHE; -; . OrthoDB EOG091G05LW; -; . PhylomeDB P68104; -; . TreeFam TF300304; -; . Reactome R-HSA-156842; Eukaryotic Translation Elongation; . Reactome R-HSA-156902; Peptide chain elongation; . Reactome R-HSA-3371511; HSF1 activation; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-8876725; Protein methylation; . SignaLink P68104; -; . SIGNOR P68104; -; . ChiTaRS EEF1A1; human; . GeneWiki Eukaryotic_translation_elongation_factor_1_alpha_1; -; . GenomeRNAi 1915; -; . PMAP-CutDB P68104; -; . PRO PR:P68104; -; . Proteomes UP000005640; Chromosome 6; . Bgee ENSG00000156508; -; . CleanEx HS_EEF1A1; -; . ExpressionAtlas P68104; baseline and differential; . Genevisible P68104; HS; . GO GO:0030864; C:cortical actin cytoskeleton; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0098574; C:cytoplasmic side of lysosomal membrane; NAS:ParkinsonsUK-UCL; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0005853; C:eukaryotic translation elongation factor 1 complex; TAS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005730; C:nucleolus; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0032587; C:ruffle membrane; IDA:UniProtKB; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0005525; F:GTP binding; TAS:UniProtKB; . GO GO:0003924; F:GTPase activity; IBA:GO_Central; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0003746; F:translation elongation factor activity; TAS:UniProtKB; . GO GO:0000049; F:tRNA binding; IDA:UniProtKB; . GO GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0006479; P:protein methylation; TAS:Reactome; . GO GO:1904714; P:regulation of chaperone-mediated autophagy; NAS:ParkinsonsUK-UCL; . GO GO:0006355; P:regulation of transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0006414; P:translational elongation; TAS:UniProtKB; . Gene3D 3.40.50.300; -; 1; . HAMAP MF_00118_A; EF_Tu_A; 1; . InterPro IPR004161; EFTu-like_2; . InterPro IPR031157; G_TR_CS; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR000795; TF_GTP-bd_dom; . InterPro IPR009000; Transl_B-barrel; . InterPro IPR009001; Transl_elong_EF1A/Init_IF2_C; . InterPro IPR004539; Transl_elong_EF1A_euk/arc; . InterPro IPR004160; Transl_elong_EFTu/EF1A_C; . Pfam PF03144; GTP_EFTU_D2; 1; . Pfam PF03143; GTP_EFTU_D3; 1; . PRINTS PR00315; ELONGATNFCT; . SUPFAM SSF50447; SSF50447; 1; . SUPFAM SSF50465; SSF50465; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR00483; EF-1_alpha; 1; . PROSITE PS00301; G_TR_1; 1; . PROSITE PS51722; G_TR_2; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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